Mannan-Oligosaccharide is an all natural complex carbohydrate which serves as a substrate for the growth of specific beneficial bacteria in the lower gut and exhibit a prebiotic-like effect that influences fecal microflora and prevents the colonization of pathogens.
Mannan-oligosaccharide benefits young animals that have a short, immature intestinal tract and are in the process of establishing a mature microflora population.  It may also have benefits during period of stress.
Mannan-oligosaccharide was extracted from outer cell wall of specific Paeciliomyces sp., Saccharomyces cerevisiae … The combination of Mannan-Oligosaccharide and β1,3-β1,6-D-Glucan considered a effective complex to activate the immune system.
(A)  Binding Pathogens:
   Mannan-Oligosaccharides occupy bacterial binding sites (lectins on  hair-like projections known as pili) on the surfaces of pathogens , thus preventing the binding of pathogens to the mucosal wall.  Mannan-Oligosaccharide binds with them and the complex can then be flushed  out of the animal.
(B)  Starving pathogens of sugars needed for growth:
   Mannan-Oligosaccharide when added to animal feed, is not digested by intestinal enzymes as animals do not have the enzymes that can act on mannan-oligosaccharide, but in fact is a substrate for the growth of beneficial bacteria.  When mannan-oligosaccharide is introduced into the GI tract, they selectively enhance the growth of beneficial lactic acid-producing bacteria like Bifidobacteria, Lactobacillus spp. and out competing and suppressing the proliferation of Gram-negative bacteria such as Escherichia coliSalmonella spp., and Clostridium perfringens.  Pathogens cannot utilize mannan-oligosaccharide, cannot multiply and are starved to death.
(C)  Stimulation of immune response:
Mannan-Oligosaccharide contains mannose and can affect the immune system by stimulation of the liver to secrete mannose binding protein.  This protein binds to the capsule of bacteria and triggers the complement "cascade" of immune response.  Mannan-Oligosaccharide  also has an adjuvant effect, i.e. increase the immunological response to drug, vaccine or antigen.  Thus mannan-oligosaccharide as a potent immuno-activator can naturally reinforce a normal healthy immune system.

Special Features of  Cenzone's Mannan-Oligosaccharide:
(A)     Extraction Of Cell Wall From Three Types Of Specially Cultured Fungi:   
     Cenzone's mannan-oligosaccharide is derived by enzymic hydrolysis of the cell wall of  three types of specially cultured fungi:  Paeciliomyces sp., Saccharomyces cerevisiae yeast and Ganoderma lucidum (reishi mushroom).  This combination of cell wall extract from three fungal species provides a broad-spectrum of pathogen binding capacity with synergistic effects.   The three types of fungi are cultured under strictly controlled conditions, are autolysed and the resulting cell wall materials are carefully and stringently separated from the intracellular fungal contents. 
(B)     Proprietary stringent LTST (Low Temperature Short Time) spray drying manufacturing process maintains the purity of the product and prevents destruction of the terminal binding sites of the mannan-oligosaccharide which are absolutely essential for maximum product efficacy. 
(C)     Phosphorylation:
          Cenzone's mannan-oligosaccharide is phosphorylated to increase pathogenic binding capacity and potentiate the immnuno-stimulating response.  Cenzone's phosphorylated mannan-oligosaccharide can effectively bind and adsorb various pathogenic bacteria including the Gram-negative Escherichia coli, Salmonella sp., Shigella sp., Vibrio sp., and some bacterias Gram positive Staphylococcus aureus, Pseudomonas sp.

The efficacy of Mannan-Oligosaccharide of CENZONE is not affected by high temperature pelleting, expander and extruder.
It remains stable in wide pH range.