β1,3-β1,6-D-Glucan is a polysaccharide, formed from glucose units, extracted from inner cell wall of specific Paeciliomyces sp., Saccharomyces cerevisiae Yeast and Ganoderma lucidum (reshi mushroom). It’s considered an immune cell activator and anti-tumor polysaccharide.

There are highly specialized receptors on the surface of large immune system cells called macrophages that can be activated by β1,3-β1,6-D-Glucan and become the "angry macrophage".  Since the macrophage is evidently unable to distinguish the β1,3D-Glucan linkage from a primary pathogen at specific receptor sites, it triggers and activates a "cascade" of immune events in much the same manner as if an actual pathogenic challenge existed. Turning the immune system into "an arsenal" of defence. 


An angry macrophage can recognize pathogenic and tumor cells non-specifically, it can also produce a number of essential cytokines (Interleukin-1  IL-1, Interleukin-6   IL-6 and Tumor Necrosis Factors) that are able to induce systemic activation. 


β1,3-β1,6-D-Glucan  enhances macrophage production dramatically and to increase non-specific host resistance to a variety of bacterial, fungal, mycotoxin, parasitic infections and tumor growth. 


β1,3-β1,6-D-Glucan has a broad spectrum of immunopharmacological activities and is beneficial in the therapy of bacterial, viral, fungal diseases.  It also enhances the effects of antibiotics. 


β1,3-β1,6-D-Glucan is the only macrophage activator that is completely non-toxic, non-pathogenic and one of the most potent stimulators of non-specific immune response.


The oral effectiveness of β1,3-β1,6-D-Glucan is proven by the fact that the fate of β1,3-β1,6-D-Glucan taken orally differs from the one for other feed additives. β1,3-β1,6-D-Glucan is acid resistant so that it passes through the stomach virtually unchanged.  Furthermore, the intestine of animals lacks a specific enzyme (β1,3-β1,6-D-Glucanase) that could break it down to glucose or di-glucose , which can be absorbed through the intestinal wall.



(A)  The configuration:

       The β1,3-β1,6-D-Glucan configuration is primarily responsible for the enhanced immune abilities, but the β1,3-β1,6-D-Glucan configuration by providing more lateral bonding sites on its molecule is more effective than the β1,3-D-Glucan configuration.  Most Beta Glucan products on the market are using the β1,3-D-Glucan as ingredient.  The β1,3-β1,6-D-Glucan is many more times more effective than the β1,3-D-Glucan in macrophage activation.

(B)  The length of molecules

The length of the β1,3-β1,6-D-Glucan molecule must consist of a minimum of 27 repetitive sugar units to be effective as a macrophage activator.  As the longer the molecule of the beta-glucan, the more bonding sites that can be used to activate the macrophages, the stronger the immuno-stimulating effects can be. Cenzone's patented and proprietary manufacturing process produces beta-glucan in the β1,3-β1,6-D-Glucan configuration and the length of the beta-glucan is a long chain of  few hundred repetitive sugar units. 

(C)  The purity of β1,3-β1,6-D-Glucan

The cell walls of the fungi Paecilomyces sp., Saccharomyces cerevisiae yeast and Ganoderma lucidum (reshi mushroom) are the sources of beta-glucan. The cell wall of these fungi is basically a glucose shell coated with an outer layer of mannoproteins. If the beta-glucan is not sufficiently purified, with the mannoprotein and fibrillar layer (the outermost layer of the fungal cell wall) intact and not removed, then the inner beta-glucan layer is not exposed -- in other words, it will not be recognized by the beta-glucan receptors on the macrophage. Most beta-glucans on the market are simply baker's yeast or crude and impure beta-glucans and will not have the full macrophage activating capability.

(D)  Micronization of Beta-Glucan

β1,3-β1,6-D-Glucan is micronized to increase the surface area so that more β1,3-β1,6-D-Glucan configuration surface will be available for attachment to the macrophage for activation.


The configuration, long chain molecule, highly purified form and the micronization of Cenzone's beta-glucan has been proven so amazingly effective as an immuno-stimulant that it is now incorporated in most of Cenzone's range of already very effective all-natural feed additives. The use of Cenzone's beta-glucan as an immuno-stimulant is unsurpassed in the animal feed industries.

The efficacy of β1,3-β1,6-D-GLUCAN of CENZONE is not affected by high temperature pelleting, expander and extruder. It remains stable in wide pH range.